Current Openings

Current Openings - Philadelphia | USA

Research Associate – Discovery, In Vitro Scientist

RESEARCH ASSOCIATE – DISCOVERY, IN VITRO SCIENTIST

Ceptur is developing unique and differentiated genetic medicines for patients with unaddressed diseases. The Company’s wholly owned and proprietary U1 Adaptor technology promotes non-genotoxic and long-lasting silencing of disease-causing genes in difficult to target tissues (i.e., outside of the liver and CNS). We are currently recruiting for a key individual to contribute to building our internal bioinformatics pipeline. The qualified individual will work in a dynamic environment and collaborate with diverse group of scientists to perform critical experiments for in vitro screening and target validation with U1 adaptors. The individual will contribute to wide range of in vitro sciences activities include cell culture work, assessing mRNA and protein levels, development of assays and fit for purpose cell models The successful candidate will be expected to display independence in the laboratory in the design, plan, and execution of in vitro experiments and provide technical input into ongoing Ceptur Discovery efforts.

Education:

BS/BA degree with at least 2 years of industry or academic experience or a MS degree in Molecular Biology, Cellular Biology or related discipline.

Required Experience:

Proven track record in biological science training in areas such as molecular biology, cellular biology, cell-based assay.
Experience in cell culture and molecular biology techniques including transfection, cell viability assays, isolation of DNA/RNA and PCR methods.
Ability to clearly present data to diverse group of scientists.

Preferred Skills:

Experience in high content biochemical and/or cellular assays and high throughput screening
Experience in RNA biology or oligonucleotide (e.g. siRNA, ASO) therapeutics.

Ceptur offers a collaborative and rewarding work environment with cutting edge scientific exploration. Ceptur offers an attractive compensation program with an extremely competitive benefits package. For more information, go to www.cepturtx.com/careers

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Scientist – Bioinformatics/Computational Biology

SCIENTIST – BIOINFORMATICS / COMPUTATIONAL BIOLOGY

Specific responsibilities include:

Design, optimize and maintain database for U1A algorithm including incorporating machine learning.
Integrate muti-omics data including human genetics, in collaboration with discovery biologists, to identify targets for unmet medical need.
Integrate various datasets to perform analyses of mRNA isoforms of target genes in normal and disease state for identifying relevant cell types for assay development.
Perform internal analyses and visualization of RNA-Seq data.

Education:

D. or M.D. in Bioinformatics, Computer Biology or related field is required
2+ postdoctoral experience in academic or industry setting to apply bioinformatics for providing insights into biological problems is preferred.

Required Skills:

Experience in RNA bioinformatics and computational Biology.
Demonstrate ability to leverage bioinformatics, statistics and data management to analyze large-scale genomics/genetics datasets for generating biological insights and hypothesis.
Clear communicator with excellent scientific writing and presentation skills. Ability to present results in visually interpretable manner to drive home key concepts.

Preferred Skills:

Experience with developing and/or applying machine learning methods to answer biomedical questions.
Previous experience in RNA Biology or oligo-based therapeutics.

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Scientist – Discovery Biology

SCIENTIST – DISCOVERY BIOLOGY

Ceptur is developing unique and differentiated genetic medicines for patients with unmet medical needs. The Company’s wholly owned and proprietary U1 Adaptor technology promotes non-genotoxic and long-lasting silencing of disease-causing genes in difficult to target tissues (i.e., outside of the liver and CNS). We are currently recruiting for a key individual to contribute to building our internal Discovery Biology group. The qualified individual will work in a dynamic environment and collaborate with diverse group of scientists to perform critical experiments for in vitro screening and target validation with U1 adaptors. The individual will contribute to wide range of discovery activities include development of assays, disease models and translatable phenotypic readout using cutting-edge techniques/platforms including patient-derived cells, CRISPR-engineering, High Content imaging and Machine Learning.

Specific responsibilities include:

Independently design and execute a wide range molecular and cell-based assays to identify U1 Adaptor leads for target manipulation.

Contribute to Target Identification and Validation efforts including developing relevant cell models for target validation efforts.
Contribute to developing and optimizing target specific assays and biological readouts for lead optimization of U1 adaptors including supporting in vivo studies.
Contribute to exploring additional U1 adaptor mechanisms for therapeutic development.
Collaborate with diverse team of bench scientists and computational biologists.

Education:

D, M.D., or M.S.in Biological Sciences,
For, Ph.D. or M.D., 2+ postdoctoral experience in professional setting in Biological Sciences is required. For M.S., 10+ years of professional experience required.

Required Skills:

Hands on experience in molecular, biochemical, and cellular techniques such as qPCR, Quantigene, Western, Immunoprecipitation, immunofluorescence, ELISAs in various cell systems.
Demonstrated knowledge and experience in utilizing cutting-edge molecular and cellular biology techniques to address mechanisms related to human diseases including Oncology, Immunology, Neurobiology and/or Rare Diseases.
Strong Team player with excellent scientific writing and presentation skills.

Preferred Skills:

Experience in developing and optimizing assays for high throughput screening.
Experience in complex cellular systems such as iPSC-derived cells and organoids.
Experience in RNA Biology or oligo-based therapeutics.

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Senior Scientist – Discovery, In Vitro/HTS Position

SENIOR SCIENTIST –DISCOVERY, IN VITRO/HTS SCIENTIST

Ceptur is developing unique and differentiated genetic medicines for patients with unmet medical needs. The Company’s wholly owned and proprietary U1 Adaptor technology promotes non-genotoxic and long-lasting silencing of disease-causing genes in difficult to target tissues (i.e., outside of the liver and CNS). We are currently recruiting for a key individual to contribute to building our internal Discovery Biology group. The qualified individual will work in a dynamic environment and collaborate with diverse group of scientists to perform critical experiments for in vitro screening and target validation with U1 adaptors. The individual will lead and contribute to wide range of in vitro sciences activities include development of assays, development of fit for purpose cell models and translatable phenotypic readout using cutting-edge techniques/platforms including patient-derived/CRISPR cells, High Content imaging and Machine Learning.

Specific responsibilities include:

Design and execute on wide range molecular, biochemical and cell-based assays to identify U1 Adaptor leads.
Demonstrated expertise in miniaturization of assays for HTS.

Developing and optimizing target specific assays and biological readouts for lead optimization of U1 adaptors including supporting in vivo studies.
Identify and implement innovative technologies for assay development to advance Discovery effort including pipeline development and exploring novel U1 adaptor mechanisms for therapeutics.
Collaborate with diverse team of bench scientists and computational biologists including mentoring junior scientists.

Education:

D or M.D with postdoctoral experience and 5+ years in biotech and/or pharmaceutical setting.

Required Skills:

Demonstrated experience in wide range of molecular, biochemical, and cellular assay development and implementation for screens.
Demonstrated experience in development of High Throughout screens including high content imaging based phenotypic screens.

Strong Team player with excellent scientific writing and presentation skills with ability to work in a cross-disciplinary settings.
Demonstrated ability to work in a fast-paced and innovative environment.
Demonstrated ability to mentor other scientists.

Preferred Skills:

Previous experience in RNA biology and/or oligo-based therapeutic.

Demonstrated experience in utilizing cutting-edge or innovative techniques including machine learning is highly desirable.
Experience in complex cellular systems such as iPSC-derived cells and organoids.

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Senior Scientist – Discover Biology

SENIOR SCIENTIST – DISCOVER BIOLOGY

Ceptur is developing unique and differentiated genetic medicines for patients with unmet medical needs. The Company’s wholly owned and proprietary U1 Adaptor technology promotes non-genotoxic and long-lasting silencing of disease-causing genes in difficult to target tissues (i.e., outside of the liver and CNS). We are currently recruiting for a key individual to contribute to building our internal Discovery Biology group. The qualified individual will work in a dynamic environment and collaborate with diverse group of scientists to perform critical experiments for in vitro screening and target validation with U1 adaptors. The individual will contribute to strategy and execution of wide range of discovery activities include development of assays, disease models and translatable phenotypic readout using cutting-edge techniques/platforms including patient-derived cells, CRISPR-engineering, High Content imaging and Machine Learning.

Specific responsibilities include:

Design and execute on wide range molecular,biochemical and cell-based assays to identify U1 Adaptor leads with expertise in RNA biology.

Contribute to Discovery strategy, Target Identification and Target Validation efforts including identifying and implementing relevant cell models for target validation efforts.
Developing and optimizing target specific assays and biological readouts for lead optimization of U1 adaptors including supporting in vivo studies.
Identify and implement innovative technologies to advance Discovery effort including pipeline development and exploring novel U1 adaptor mechanisms for therapeutics.
Collaborate with diverse team of bench scientists and computational biologists including mentoring junior scientists.

Education:

D or M.D with postdoctoral experience and 5+ years in professional setting in Biological Sciences is required.

Required Skills:

Demonstrated experience in molecular, biochemical, and cellular techniques such as qPCR, Quantigene, Western, Immunoprecipitation, immunofluorescence, ELISAs in various cell systems.

Demonstrated track record in utilizing cutting-edge molecular and cellular biology techniques to address mechanisms related to human diseases including Oncology, Immunology, Neurobiology and/or Rare Diseases.
Experience in complex cellular systems such as iPSC-derived cells and organoids.
Strong Team player with excellent scientific writing and presentation skills with ability to work in a cross-disciplinary settings.
Demonstrated ability to work in a fast-paced and innovative environment.
Demonstrated ability to mentor other scientists.

Preferred Skills:

Demonstrated experience in RNA Biology or oligo-based therapeutics.
Experience in drug discovery.

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Senior Scientist – Bioinformatics/Computational Biology

SENIOR SCIENTIST – BIOINFORATICS / COMPUTATIONAL BIOLOGY

Specific responsibilities include:

Lead design, optimize and maintain database for U1A algorithm.
Demonstrated experience with machine learning for biological problems.
Integrate and analyze muti-omics data including human genetics, in collaboration with discovery biologists, to identify targets for unmet medical need.
Integrate various datasets to perform analyses of mRNA isoforms of target genes in normal and disease state for identifying relevant cell types for assay development.
Lead development of internal pipeline for analyses and visualization of RNA-Seq data.

Education:

D. or M.D. in Bioinformatics, Computer Biology or related field is required
Postdoctoral experience and 5+ years of professional experience in industry or academics

Required Skills:

Demonstrate ability to leverage bioinformatics, statistics and data management to analyze large-scale genomics/genetics datasets for generating biological insights and hypothesis.
Experience with developing and/or applying machine learning methods to answer biomedical questions.
Clear communicator with excellent scientific writing and presentation skills. Ability to present results in visually interpretable manner to drive home key concepts.
Strong Team player with ability to work in a cross-disciplinary settings.
Demonstrated ability to work in a fast-paced and innovative environment.
Demonstrated ability to mentor other scientists.

Preferred Skills:

Experience in bioinformatics and computational Biology in RNA Biology or Oligo-based therapeutics.
Experience in drug development.

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Current Openings - Copenhagen | Denmark

Laborant (Lab technician), Nucleotide Chemistry/Oligonucleotide Synthesis

LABORANT (LAB TECHNICIAN), NUCLEOTIDE CHEMISTRY / OLIGONUCLEOTIDE SYNTHESIS

Ceptur Therapeutics is developing unique and differentiated genetic medicines for patients with unaddressed diseases. The Company’s wholly owned and proprietary U1 Adaptor technology promotes non-genotoxic and long-lasting silencing of disease-causing genes in difficult to target tissues (i.e., outside of the liver and CNS). We are currently recruiting for a key individual to contribute to building our internal bioinformatics pipeline. The qualified individual will work in a dynamic environment and collaborate with diverse group of scientists to perform critical bioinformatic analyses for identifying optimal U1 Adaptors, gene expression including RNA isoforms and target identification including leveraging human genetics.

Stillingen

Vi søger en motiveret kollega til en stilling som laborant til arbejdsopgaver inden for lægemiddeludvikling. Du vil blive ansat i oligonukleotid syntese gruppen, der er ansvarlig for at levere aktive stoffer til Drug Discovery projekter. Gruppens arbejdsopgaver omfatter alt fra syntese, oprensning, QC og til formulering af de aktive stoffer.

Syntese, oprensning og analyse af oligonukleotider i mg til g skala
Vedligeholdelse af instrumenter
Behandling og afrapportering af resultater
Udarbejdelse af procedurer
Formulering af oligonukleotider til in-vitro og in-vivo forsøg
Klargøring og forsendelse af prøver til andre sites

Hvem er du

Vi forventer at du arbejder selvstændigt, er fleksibel og har gode samarbejdsevner. Du har lyst til at arbejde i et selskab hvor dynamik, samarbejde, kreativitet og resultater er højt prioriteret. Derudover regner vi med du er/har:

Laborant eller laboratorietekniker af uddannelse
Erfaring fra biotek eller Pharma industrien
Gerne erfaring med fastfase syntese
Erfaring med instrumenter og automatisering
Omhyggelig, omgængelig, har gode samarbejdsevner og kan arbejde selvstændigt
Trives i et uformelt og til tider omskifteligt miljø
Kan have mange bolde i luften samtidigt, og finder glæde i at opnå de aftalte mål

Interested in a discussion about how you can contribute? Forward a resume to us at conta[email protected]

Program Manager

PROGRAM MANAGER

Role Summary:

You will be part of Project Management organization in R&D, and you will work in close collaboration with colleagues across Ceptur Therapeutics both in Denmark and in US, external partners, CDMOs and CROs. The development projects will be within oligonucleotides and bioconjugates and the projects will span from early research to IND enabling activities.

Specific responsibilities include:

As a Project Manager you will prepare and execute the development strategy and plan the project scenarios. You will be responsible for the cross-organizational execution of project activities and in this connection interact with internal stakeholders and external CMO/CROs and Partners
Establishing/leading cross-functional project teams ensuring and selecting adequate competences and resources in collaboration with the line organization.
Establishing and executing activities according to project plans supporting the objective of the projects, with a continuous focus on value creation and optimization of time to market/ project finalization.
Project budgeting, resources planning and overview.
Ensuring establishment of project plans and recommendations in support of strategic decisions to be made.
Project reporting and communication, risk management
As required, provide project management / leadership for organizational improvement projects with the aim of developing/improving business processes

Education:

You hold an academic degree (usually at Masters or PhD level) in a relevant scientific discipline with a minimum of 5 years’ experience with project management in the pharmaceutical or biopharmaceutical industries and supplemented with formal project management education.

Required Skills:

Broad knowledge within development of oligonucleotides or biopharmaceuticals, gained from working a number of years within several relevant fields of expertise.
Good understanding of the biopharmaceutical or pharmaceutical value stream.
Ability to include different perspectives through professional standard knowledge of areas across functions.
Relevant formal project management education and knowledge of project management principles and practices.
Strong organisational and business understanding.
Excellent communication skills – internally and externally, orally and in writing in English and preferably Danish.

Preferred Skills:

Experiences with leading different types of projects and with working in a matrix organization across cultures and time zones.
Effective facilitation skills.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Scientist or Sr. Scientist, Nucleotide Chemistry/Oligonucleotide Synthesis

SCIENTIST OR SENIOR SCIENTIST, NUCLEOTIDE CHEMISTRY / OLIGONUCLEOTIDE SYSNTHESIS

Role Summary:

We are currently seeking a motivated and creative scientist with expertise in solid phase oligonucleotide synthesis to join our growing nucleotide/oligonucleotide chemistry and delivery team. In this position, you will play a key role in building up Cepturs synthetic chemistry group and set up new synthesis/purification workflows and labs to produce high quality synthetic oligonucleotides for research and preclinical drug development. The successful candidate will have significant experience with hands-on operation of lab-scale oligonucleotide synthesizers. The ideal candidate will be comfortable working in a cross-functional role and excel as part of a diverse team.

Specific responsibilities include:

Develop, establish, and evaluate solid-phase synthesis and downstream purification and analytical methods of guide natural and chemically modified oligonucleotides
Execute solid phase syntheses to produce high quality U1 adaptors with chemical modifications to support Ceptur’s research programs
Actively evaluate effectiveness of the oligonucleotides synthesis and improve synthetic, purification, and analytical protocols
Provide technical guidance on design and chemical modifications for small to mid-scale synthesis of lU1 adaptors for in vitro and in vivo screening
Author, review, and approve protocols, SOPs, technical documents, and reports for synthesis lab
Independently plan and execute experiments, perform data analysis and interpretation
Deliver reproducible and impactful results under ambitious timelines
Understand the landscape of clinical and process materials, liaison with vendors, and maintain appropriate inventory
Maintain thorough electronic lab notebooks and documentation records, and present findings to multi-disciplinary teams in various oral and written formats
Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies

Education:

PhD in Chemistry, Biochemistry, Biotechnology, or related field

Required Skills:

0-5 years of experience in an industrial setting
Deep understanding of solid phase oligonucleotide synthesis chemistry, anion-exchange chromatography, reverse-phase chromatography, and size-exclusion chromatography.
Demonstrated competency in setting up and operating lab-scale oligonucleotide synthesizers, such as the MerMade 12, MerMade 48X, AKTA OligoPilot 100 and Dr oligo 48.
Demonstrated competency in HPLC/UPLC purifications, analysis, and characterization methods of oligonucleotides
Highly self-motivated, driven, can-do, make it happen attitude with ability to own and drive projects

Preferred Skills:

Experience with analytical techniques for the analysis of chemically modified DNA/RNA oligonucleotides, such as HPLC/UPLC, UV thermal melting, LC-UV-Fluor, LC-MS, and capillary electrophoresis
Strong collaborator with cross-functional teams and external partners
Capable of continuous learning, open-minded, curious, highly organized, and detail-oriented

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

Principal Scientist or Associate Director, Nucleotide Chemistry/Oligonucleotide Synthesis

PRINCIPAL SCIENTIST OR ASSOCIATE DIRECTOR, NUCLEOTIDE CHEMISTRY / OLIGONUCLEOTIDE SYNTHESIS

Role Summary:

The Prin. Scientist or Ass. Director of Oligonucleotide Synthesis will report to to the CTO based in Copenhagen. and is responsible for leading oligo design, manufacturing, and purification at Ceptur. S/he will manage internal and external oligo synthesis, analytics, and characterization of U1 apadtor chemistries. Candidate will be a subject matter expert in the understanding of testing, scale-up and manufacturing of nucleic acid drugs with a comprehensive understanding of oligo delivery and formulations. Knowlegde at cGMP is considered a plus. S/he will collaborate closely with additional chemistry, biology, and research teams both in Denmark and USA, supporting all stages of research and preclinical therapeutic development. Candidate will use creative and proactive problem-solving strategies to progress oligo design and development in support of Ceptur’s U1A apadtor pipeline. S/he will act as an effective technical expert and work in a collaborative, constructive and mission-oriented focus for improving the lives of patients.

Specific responsibilities include:

Provide subject matter expertise on internal oligonucleotide synthesis
Lead oligonucleotide design and innovation strategies to support preclinical programs
Collaborate with internal and external teams to troubleshoot and optimize oligonucleotide sequences to coincide with the organization’s goals
Evaluate, validate, and implement new technologies and techniques both internally and with CROs
Manage a small team of scientist
Prepare manuscripts and other documents for publication and/or regulatory submission.

Education:

D. in Chemistry, Biochemistry, or a related discipline

Required Skills:

Minimum of 10 years of experience with drug design and development
Highly advanced knowledge of design, synthesis, and purification of nucleic acids and oligonucleotides
Previous exposure to scale-up manufacturing
Proven leadership and interpersonal skills, including ability to work across functional lines.
Ability to select and manage third-party vendors and collaborators, communicate technical information and work with all levels and functions within the Company.
Excellent written and verbal communication skills (danish and English), including making effective and compelling presentations in both large and small groups and communicating complex scientific and nonscientific issues.

Preferred Skills:

Background in organic chemistry, specifically peptide synthesis and/or conjugation is preferred
Experience with CRO selection, validation, and management

Interested in a discussion about how you can contribute? Forward a resume to us at [email protected]

You may also apply for current openings on the Ceptur Therapeutics company page on Indeed.com: